The network includes no. 5 bus lines of national interest aimed at connecting the Gargano area and Termoli with Rome, Rome Fiumicino airport and the most important towns in central-northern Italy such as Florence, Empoli, Livorno, Pisa, Verona, Trento, Bolzano, Brescia , Bergamo, La Spezia, Turin, Ferrara, Padua, Vicenza, Parma, Modena, Reggio Emilia, Salsomaggiore Terme (summer service), with the Abruzzo centers of Pescara and Chieti Scalo and with San Benedetto del Tronto, Civitanova Marche and Macerata.
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